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Dr. Lily Houghton enlists the aid of wisecracking skipper Frank Wolff to take her down the Amazon in his ramshackle boat. Together, they search for an ancient tree that holds the power to heal — a discovery that will change the future of medicine. Rated PG-13
Starring: Emily Blunt, Dwayne “The Rock” Johnson, Jack Whitehall, Jesse Plemmons, Edgar Ramirez
Directed By: Jaume Collet-Serra | Written By: Michael Green, Glenn Ficarra, John Requa, John Norville, Josh Goldstein
Production Company: Walt Disney Studios
| Week | Weekend Grossing ($/Million) | Total Grossing ($/Million) | Weekend Of |
| 1 | $35,018,731 | $35,018,731 | 30 July to 1 Aug |
| 2 | $15,818,590 | $65,443,044 | 6 Aug to 8 Aug |
| 3 | $9,120,000 | $82,270,000 | 13 Aug to 15 Aug |
| 4 | $5,002,136 | $100,092,318 | 20 Aug to 22 Aug |
| 5 | $5,000,000 | $100,100,000 | 27 Aug to 29 Aug |
| 6 | $4,010,000 | $105,710,000 | 3 Sept to 5 Sept |
| 7 | $2,450,000 | $109,900,000 | 10 Sept to 12 Sept |
| 8 | $2,077,076 | $112,571,412 | 17 Sept to 19 Sept |
